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5-oxoETE links redox control of epithelial damage detection and resilience

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11121-2The DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes that protect epithelial redox integrity.

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Oct 8, 2026 - 02:00
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5-oxoETE links redox control of epithelial damage detection and resilience

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11121-2The DHRS7–OXER1 pathway links oxidative stress to immunity and tissue resilience by modulating 5-oxoETE via NADP+–NADPH, activating OXER1 to recruit antimicrobial cells and induce NUDIX enzymes that protect epithelial redox integrity.

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