A cholinergic hub in the nucleus accumbens gates opioid-reward learning
Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10887-9Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing analgesia and decouples morphine-evoked dopamine elevations from acetylcholine dips, suggesting pro-cholinergic strategies to limit early opioid reward acquisition.
Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10887-9Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing analgesia and decouples morphine-evoked dopamine elevations from acetylcholine dips, suggesting pro-cholinergic strategies to limit early opioid reward acquisition.
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