A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11142-xThe administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.

SINSIN
Oct 7, 2026 - 23:00
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A gut microbial odd-chain fatty acid alleviates atherosclerosis in mice

Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11142-xThe administration of Bacteroides uniformis in mice can mitigate atherosclerosis via pentadecanoic acid, which directly inhibits HMG-CoA reductase to promote hepatic cholesterol clearance.

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