A tumour-derived organoid biobank maps cancer gene dependencies

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10830-yA clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatment-driven changes, expanding mechanistic insight and models for precision oncology.

SINSIN
Aug 5, 2026 - 22:00
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A tumour-derived organoid biobank maps cancer gene dependencies

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10830-yA clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatment-driven changes, expanding mechanistic insight and models for precision oncology.

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