Domain-alteration chimeras rewire oncogenic complexes in prostate cancer
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11262-4A novel therapeutic modality enforces non-native androgen receptor (AR)–p300/CBP interactions to collapse AR transcriptional programs, producing super-inhibitory, lineage-selective suppression of metastatic prostate cancer and establishing domain-alteration chimeras as a broadly applicable therapeutic strategy leveraging induced proximity.
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11262-4A novel therapeutic modality enforces non-native androgen receptor (AR)–p300/CBP interactions to collapse AR transcriptional programs, producing super-inhibitory, lineage-selective suppression of metastatic prostate cancer and establishing domain-alteration chimeras as a broadly applicable therapeutic strategy leveraging induced proximity.
What's Your Reaction?
SIN
ScienceX Information Network (SIN) | ScienceX Innovations
