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GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10786-zChimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced hepatocellular carcinoma who have developed resistance or not responded to previous treatment.

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Jul 16, 2026 - 22:00
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GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

Nature, Published online: 15 July 2026; doi:10.1038/s41586-026-10786-zChimeric antigen receptor (CAR) T cells for antitumour therapy ‘armoured’ with a dominant-negative TGFβ receptor II show enhanced efficacy and tolerable safety in patients with advanced hepatocellular carcinoma who have developed resistance or not responded to previous treatment.

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