Life

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-yProteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

SINSIN
Oct 22, 2026 - 00:00
 0  3
GRP75-dependent SIMPA mediates inter-organellar quality control

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-10733-yProteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling selective clearance of damaged proteins and preserving mitochondrial integrity.

Read More

Tags:

Previous Article

Science on the Space Station with NASA Astronaut Jessica Watkins

Next Article

An environmentally regulated dichotomy in cell lineages of the root

What's Your Reaction?

like

dislike

love

funny

angry

sad

wow

SIN
SIN ScienceX Information Network (SIN) | ScienceX Innovations

Related Posts

Electrically controllable superconducting memory effect in UTe<sub>2</sub>

Electrically controllable superconducting memory effect...

SIN Sep 16, 2026  0  31

Chemistry Nobel for solving mystery of how ‘handed’ organic molecules can emerge

Chemistry Nobel for solving mystery of how ‘handed’ org...

SIN Oct 7, 2026  0  21

What to do when you have too many PhD projects on the go

What to do when you have too many PhD projects on the go

SIN Aug 10, 2026  0  32