Head-to-head trial shows Eli Lilly’s oral GLP-1 orforglipron outperforms oral semaglutide

A new trial found that Eli Lilly’s GLP-1 pill resulted in greater reductions in blood sugar levels and weight than oral semaglutide did, but fewer people stayed on it

SINSIN
Feb 27, 2026 - 05:00
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Head-to-head trial shows Eli Lilly’s oral GLP-1 orforglipron outperforms oral semaglutide

A new trial found that Eli Lilly’s GLP-1 pill resulted in greater reductions in blood sugar levels and weight than oral semaglutide did, but fewer people stayed on it

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