MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac energetics and preventing stress-induced heart failure.
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to pyruvate and NADH, sustaining cardiac energetics and preventing stress-induced heart failure.
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