Persistent neuronal stress signalling underlies Angelman syndrome phenotypes
Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.
Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11165-4Genetic and proteomic analyses in human neurons and mouse models of Angelman syndrome (AS) show that loss of the ubiquitin ligase UBE3A leads to an overabundance of asparagine synthetase, and that this is linked with many AS phenotypes.
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