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T and B cells recognize splicing-derived neutrophil neoantigens in lupus

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11219-7In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing neoantigen-driven autoimmune immunity.

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Oct 29, 2026 - 18:00
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T and B cells recognize splicing-derived neutrophil neoantigens in lupus

Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11219-7In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing neoantigen-driven autoimmune immunity.

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