Transcription pause and elongation regulators mediate somatic hypermutation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11092-4The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are identified.

SINSIN
Oct 1, 2026 - 17:00
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Transcription pause and elongation regulators mediate somatic hypermutation

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11092-4The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled polymerase II substrate during somatic hypermutation are identified.

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