<i>UNC13A</i> splice correction rescues synaptic dysfunction induced by TDP-43 loss
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11256-2TDP-43 loss induces a predegenerative state in which neurons remain structurally intact and suffer a substantial breakdown in synaptic communication; a therapeutic strategy is found that corrects UNC13A cryptic splicing by using splice-switching antisense oligonucleotides.
Nature, Published online: 11 November 2026; doi:10.1038/s41586-026-11256-2TDP-43 loss induces a predegenerative state in which neurons remain structurally intact and suffer a substantial breakdown in synaptic communication; a therapeutic strategy is found that corrects UNC13A cryptic splicing by using splice-switching antisense oligonucleotides.
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