Life

WEE1 opposes APC/C<sup>CDH1</sup> activity to promote S phase entry

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-xExperimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

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Oct 22, 2026 - 00:00
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WEE1 opposes APC/C<sup>CDH1</sup> activity to promote S phase entry

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11188-xExperimental and modelling data indicate that WEE1 promotes re-entry of quiescent cells into the cell cycle, potentially explaining the toxic side effects of WEE1 inhibitors in cancer therapies.

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