Aneuploidy selects for the acquisition of driver genes in breast cancer
Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10752-9Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species.
Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10752-9Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species.
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