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Efficient and precise programmable DNA knock-in without double-strand breaks

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.

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Jul 22, 2026 - 22:00
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Efficient and precise programmable DNA knock-in without double-strand breaks

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.

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