Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10909-6Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate models.

SINSIN
Aug 12, 2026 - 22:00
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Glucose-responsive probiotics for glycaemic modulation in mice and monkeys

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10909-6Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-respond control of diabetes in mouse and primate models.

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