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Intestinal stem cells count self-renewal divisions to switch multipotency

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10814-yIn Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing an enteroendocrine mother cell every ninth division.

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Jul 29, 2026 - 22:00
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Intestinal stem cells count self-renewal divisions to switch multipotency

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10814-yIn Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing an enteroendocrine mother cell every ninth division.

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