Microbiome-wide PheWAS links gut microbial SNVs to health and exposures

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11220-0Gut microbial single-nucleotide variants across 10,781 individuals reveal 940 associations that link strain-level genetic variation to 69 host traits, with structural analyses pinpointing host phenotype-associated variants, providing a base pair-resolution resource for mechanistic hypothesis generation.

SINSIN
Nov 5, 2026 - 00:00
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Microbiome-wide PheWAS links gut microbial SNVs to health and exposures

Nature, Published online: 04 November 2026; doi:10.1038/s41586-026-11220-0Gut microbial single-nucleotide variants across 10,781 individuals reveal 940 associations that link strain-level genetic variation to 69 host traits, with structural analyses pinpointing host phenotype-associated variants, providing a base pair-resolution resource for mechanistic hypothesis generation.

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