MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11048-8Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, suggesting that Polθ disruption may destabilize ecDNA and sensitize ecDNA-driven tumours to therapeutic intervention.
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11048-8Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, suggesting that Polθ disruption may destabilize ecDNA and sensitize ecDNA-driven tumours to therapeutic intervention.
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