Prior therapy defines mutation profiles in childhood cancer at relapse
Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10803-1Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, highlighting therapy-induced tumour evolution and opportunities for safer, de-escalated treatment.
Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10803-1Chemotherapy, particularly with platinum-based drugs, is associated with substantial, rapidly detectable mutagenesis in childhood cancers, tripling private signatures and doubling mutation burden, highlighting therapy-induced tumour evolution and opportunities for safer, de-escalated treatment.
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