Relapsed childhood cancers show genomic scars left by previous therapy
Nature, Published online: 29 July 2026; doi:10.1038/d41586-026-02329-3Whole-genome sequencing of hundreds of childhood tumours, enriched for pretreated, relapsed and metastatic samples, shows that cancer therapies, especially platinum-based ones, are associated with rapid acquisition of distinctive patterns of DNA damage. These mutational signatures are linked with worse outcomes and could be used to track relapses and guide treatment decisions.
Nature, Published online: 29 July 2026; doi:10.1038/d41586-026-02329-3Whole-genome sequencing of hundreds of childhood tumours, enriched for pretreated, relapsed and metastatic samples, shows that cancer therapies, especially platinum-based ones, are associated with rapid acquisition of distinctive patterns of DNA damage. These mutational signatures are linked with worse outcomes and could be used to track relapses and guide treatment decisions.
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