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Structural mechanism governing the directionality of bridge recombination

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-yCryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.

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Aug 13, 2026 - 16:00
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Structural mechanism governing the directionality of bridge recombination

Nature, Published online: 12 August 2026; doi:10.1038/s41586-026-10903-yCryo-electron microscopy structures show how IS621 bridge recombinase mediates DNA excision, explaining its natural preference for insertion and informing the design of programmable bridge-editing technologies.

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