Structure and operating principles of a monkeypox virus replisome
Nature, Published online: 02 September 2026; doi:10.1038/s41586-026-10937-2During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 thumb domain and A22 subunit, activating the helicase–primase.
Nature, Published online: 02 September 2026; doi:10.1038/s41586-026-10937-2During replisome assembly of monkeypox virus, the hexameric helicase–primase E5 undergoes large-scale conformational changes that allow two of its primase domains to interact with the polymerase F8 thumb domain and A22 subunit, activating the helicase–primase.
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