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A biased allosteric modulator is a molecular glue for β<sub>2</sub>AR dimerization

Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10892-yAP-7-168, an optimized derivative of a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR), functions as a molecular glue to stabilize β2AR homodimerization.

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Aug 20, 2026 - 01:00
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A biased allosteric modulator is a molecular glue for β<sub>2</sub>AR dimerization

Nature, Published online: 19 August 2026; doi:10.1038/s41586-026-10892-yAP-7-168, an optimized derivative of a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR), functions as a molecular glue to stabilize β2AR homodimerization.

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