Osteoclasts intercept meningeal lymphatic paths for dural metastasis
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11082-6Osteoclast-derived angiopoietin-2 in the dura mater impairs lymphatic vessel function and weakens anti-tumour immunity against dural metastases, which offers new therapeutic approaches to restore meningeal lymphatic function through selective osteoclast targeting.
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11082-6Osteoclast-derived angiopoietin-2 in the dura mater impairs lymphatic vessel function and weakens anti-tumour immunity against dural metastases, which offers new therapeutic approaches to restore meningeal lymphatic function through selective osteoclast targeting.
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